Anti-APLP1 Antibody

Rs. 45,619.00
SKU stj22642

General Information

Product name Anti-APLP1 Antibody
Short Description Rabbit polyclonal to APLP1
Description This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Anti-APLP1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 39-300 of human APLP1 (NP_005157.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 72.2 kDa
Database Links
Alternative Names APLP1Amyloid-like protein 1 antibodyAPLP antibodyAPLP-1APLP1
Function May play a role in postsynaptic function, The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity), Couples to JIP signal transduction through C-terminal binding, May interact with cellular G-protein signaling pathways, Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
Cellular Localization Cell membrane
Tissue Specificity Expressed in the cerebral cortex where it is localized to the postsynaptic density (psd).
Swiss-Prot Key

 

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