Anti-APOBEC3D Antibody

Rs. 57,098.00
SKU stj71425

General Information

Product name Anti-APOBEC3D Antibody
Short Description Goat polyclonal to APOBEC3D
Description
Applications ELISA
Dilution range
Protein Name Anti-APOBEC3D Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 46.6 kDa
Database Links
Alternative Names APOBEC3DDNA dC->dU-editing enzyme APOBEC-3D antibodyA3DAPOBEC3D
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms, Exhibits antiviral activity against vif-deficient HIV-1, After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA, The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells, Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA, May inhibit the mobility of LTR and non-LTR retrotransposons,
Cellular Localization Cytoplasm, Cytoplasm, P-body
Tissue Specificity Expressed in lymphoid organs, also detected in non-lymphoid tissues including lung,
Swiss-Prot Key

 

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