Anti-APOBEC3F Antibody

Rs. 45,619.00
SKU stj22650

General Information

Product name Anti-APOBEC3F Antibody
Short Description Rabbit polyclonal to APOBEC3F
Description This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-APOBEC3F Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 189-373 of human APOBEC3F (NP_660341.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 45 kDa
Database Links
Alternative Names APOBEC3FDNA dC->dU-editing enzyme APOBEC-3F APOBEC3F
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms, Exhibits antiviral activity against vif-deficient HIV-1, After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA, The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells, Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA, Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons, May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Cellular Localization Cytoplasm, Cytoplasm, P-body
Tissue Specificity Widely expressed, highly expressed in ovary.
Swiss-Prot Key

 

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