Anti-APOBEC3G Antibody

Rs. 45,619.00
SKU stj22651

General Information

Product name Anti-APOBEC3G Antibody
Short Description Rabbit polyclonal to APOBEC3G
Description This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene catalyzes site-specific deamination of both RNA and single-stranded DNA. The encoded protein has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-APOBEC3G Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 60-330 of human APOBEC3G (NP_068594.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 46.4 kDa
Database Links
Alternative Names APOBEC3GDNA dC->dU-editing enzyme APOBEC-3G APOBEC3G antibodyMDS019
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms, Exhibits potent antiviral activity against vif-deficient HIV-1, After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA, The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells, Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA, Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV), May inhibit the mobility of LTR and non-LTR retrotransposons.
Cellular Localization Cytoplasm, Nucleus, Cytoplasm, P-body.
Tissue Specificity Expressed in spleen, testes, ovary and peripheral blood leukocytes and cd4+ lymphocytes, also expressed in non-permissive peripheral blood mononuclear cells, and several tumor cell lines
Swiss-Prot Key

 

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