Anti-APOBEC3G Antibody

Rs. 68,577.00
SKU stj71155

General Information

Product name Anti-APOBEC3G Antibody
Short Description Goat polyclonal to APOBEC3G
Description
Applications ELISA, WB, IHC
Dilution range
Protein Name Anti-APOBEC3G Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 46.4 kDa
Database Links
Alternative Names APOBEC3GDNA dC->dU-editing enzyme APOBEC-3G APOBEC3G antibodyMDS019
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms, Exhibits potent antiviral activity against vif-deficient HIV-1, After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA, The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells, Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA, Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV), May inhibit the mobility of LTR and non-LTR retrotransposons,
Cellular Localization Cytoplasm, Nucleus, Cytoplasm, P-body,
Tissue Specificity Expressed in spleen, testes, ovary and peripheral blood leukocytes and cd4+ lymphocytes, also expressed in non-permissive peripheral blood mononuclear cells, and several tumor cell lines
Swiss-Prot Key

 

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