Anti-ApoE Antibody

Rs. 45,619.00
SKU stj29789

General Information

Product name Anti-ApoE Antibody
Short Description Rabbit polyclonal to APOE
Description The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Applications IHC,IF
Dilution range IHC 1:50 - 1:100
IF 1:50 - 1:100
Protein Name Anti-ApoE Antibody
Immunogen A synthetic peptide corresponding to a sequence within amino acids 200-300 of human APOE (NP_000032.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 36.2 kDa
Database Links
Alternative Names APOEApolipoprotein E antibodyApo-EAPOE
Function Mediates the binding, internalization, and catabolism of lipoprotein particles, It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Cellular Localization Secreted
Tissue Specificity Occurs in all lipoprotein fractions in plasma, it constitutes 10-20% of very low density lipoproteins (vldl) and 1-2% of high density lipoproteins (hdl), apoe is produced in most organs, significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle
Swiss-Prot Key

 

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