Anti-APP Antibody

Rs. 45,619.00
SKU stj113456

General Information

Product name Anti-APP Antibody
Short Description Rabbit monoclonal to APP
Description This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Applications WB,IHC,ICC,IF,IP,FC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
ICC 1:50 - 1:200
IF 1:50 - 1:100
IP 1:20 - 1:50
FC 1:20 - 1:50
Protein Name Amyloid-beta A4 proteinABPPAPPIAPPAlzheimer disease amyloid proteinAmyloid precursor proteinAmyloid-beta precursor proteinCerebral vascular amyloid peptideCVAPPreA4Protease nexin-IIPN-II
Immunogen Recombinant protein of human APP
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Monoclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 86.9 kDa
Database Links
Alternative Names APPAmyloid-beta A4 protein antibodyABPP antibodyAPPI antibodyAPP antibodyAlzheimer disease amyloid protein antibodyAmyloid precursor protein antibodyAmyloid-beta precursor protein antibodyCerebral vascular amyloid peptide antibodyCVAP antibodyPreA4 antibodyProtease nexin-II antibodyPN-IIAPP antibodyA4 antibodyAD1
Function Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis, Involved in cell mobility and transcription regulation through protein-protein interactions, Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb, Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP, Inhibits G(o) alpha ATPase activity (By similarity), Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1, Involved in copper homeostasis/oxidative stress through copper ion reduction, In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation, Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV, The splice isoforms that contain the BPTI domain possess protease inhibitor activity, Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons, Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.
Cellular Localization Membrane
Tissue Specificity Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen, weak expression in liver, in adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex, weak expression found in the striate, extra-striate and motor cortices, expressed in cerebrospinal fluid, and plasma, isoform app695 is the predominant form in neuronal tissue, isoform app751 and isoform app770 are widely expressed in non-neuronal cells, isoform app751 is the most abundant form in t-lymphocytes, appican is expressed in astrocytes.
Swiss-Prot Key

 

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