Anti-AQP3 Antibody

Rs. 45,619.00
SKU stj22660

General Information

Product name Anti-AQP3 Antibody
Short Description Rabbit polyclonal to AQP3
Description This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-AQP3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 178-292 of human AQP3 (NP_004916.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 31.5 kDa
Database Links
Alternative Names AQP3Aquaporin-3 antibodyAQP-3 antibodyAquaglyceroporin-3AQP3
Function Water channel required to promote glycerol permeability and water transport across cell membranes, Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content, Involved in skin hydration, wound healing, and tumorigenesis, Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient, Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells, It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
Cellular Localization Basolateral cell membrane
Tissue Specificity Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes, isoform 2 is not detectable in erythrocytes at the protein level
Swiss-Prot Key

 

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