Anti-ARFGAP1 Antibody

Rs. 45,619.00
SKU stj114469

General Information

Product name Anti-ARFGAP1 Antibody
Short Description Rabbit polyclonal to ARFGAP1
Description The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name ADP-ribosylation factor GTPase-activating protein 1ARF GAP 1ADP-ribosylation factor 1 GTPase-activating proteinARF1 GAPARF1-directed GTPase-activating protein
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ARFGAP1 (NP_001268411.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 44.7 kDa
Database Links
Alternative Names ARFGAP1ADP-ribosylation factor GTPase-activating protein 1 antibodyARF GAP 1 antibodyADP-ribosylation factor 1 GTPase-activating protein antibodyARF1 GAP antibodyARF1-directed GTPase-activating proteinARFGAP1 antibodyARF1GAP
Function GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1), Involved in membrane trafficking and /or vesicle transport, Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment, Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2, Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated, Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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