Anti-ARG2 Antibody

Rs. 45,619.00
SKU stj28438

General Information

Product name Anti-ARG2 Antibody
Short Description Rabbit polyclonal to ARG2
Description Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ARG2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-354 of human ARG2 (NP_001163.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 38.6 kDa
Database Links
Alternative Names ARG2Arginase-2 antibodymitochondrial ARG2
Function May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis, Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS), Arginine metabolism is a critical regulator of innate and adaptive immune responses, Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells.
Cellular Localization Mitochondrion
Tissue Specificity Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas, expressed in activated t cells.
Swiss-Prot Key

 

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