Anti-ARHGEF1 Antibody

Rs. 45,619.00
SKU stj116239

General Information

Product name Anti-ARHGEF1 Antibody
Short Description Rabbit polyclonal to ARHGEF1
Description Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
Applications WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Rho guanine nucleotide exchange factor 1115 kDa guanine nucleotide exchange factorp115-RhoGEFp115RhoGEFSub1.5
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 783-912 of human ARHGEF1 (NP_004697.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 102.4 kDa
Database Links
Alternative Names ARHGEF1Rho guanine nucleotide exchange factor 1 antibody115 kDa guanine nucleotide exchange factor antibodyp115-RhoGEF antibodyp115RhoGEF antibodySub1.5ARHGEF1
Function Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits, Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase, Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain, This GEF activity is inhibited by binding to activated GNA12, Mediates angiotensin-2-induced RhoA activation.
Cellular Localization Cytoplasm.
Tissue Specificity Ubiquitously expressed.
Swiss-Prot Key

 

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