Anti-ARHGEF2 Antibody

Rs. 45,619.00
SKU stj114421

General Information

Product name Anti-ARHGEF2 Antibody
Short Description Rabbit polyclonal to ARHGEF2
Description Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.
Applications IHC
Dilution range IHC 1:50 - 1:100
Protein Name Rho guanine nucleotide exchange factor 2Guanine nucleotide exchange factor H1GEF-H1Microtubule-regulated Rho-GEFProliferating cell nucleolar antigen p40
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human ARHGEF2 (NP_004714.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 111.5 kDa
Database Links
Alternative Names ARHGEF2Rho guanine nucleotide exchange factor 2 antibodyGuanine nucleotide exchange factor H1 antibodyGEF-H1 antibodyMicrotubule-regulated Rho-GEF antibodyProliferating cell nucleolar antigen p40ARHGEF2 antibodyKIAA0651 antibodyLFP40
Function Activates Rho-GTPases by promoting the exchange of GDP for GTP, May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer, Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026, May stimulate instead the cortical activity of Rac, Inactive toward CDC42, TC10, or Ras-GTPases, Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens, Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S,flexneri cell invasion, Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA, Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans
Cellular Localization Cytoplasm, cytoskeleton.
Tissue Specificity
Swiss-Prot Key

 

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