Anti-Arkadia antibody

Rs. 50,211.00
SKU stj91694

General Information

Product name Anti-Arkadia antibody
Short Description
Description Rabbit polyclonal to Arkadia.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:40000
Protein Name Anti-Arkadia antibody
Immunogen Synthesized peptide derived from human Arkadia
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 110 kDa
Database Links
Alternative Names E3 ubiquitin-protein ligase Arkadia antibody
RING finger protein 111 antibody
hRNF111 antibody
RING-type E3 ubiquitin transferase RNF111 antibody
Function E3 ubiquitin-protein ligase . Required for mesoderm patterning during embryonic development . Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP . Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP . In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded . Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL . Associates with UBE2D2 as an E2 enzyme . Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates . Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair . Mediates ubiquitination and degradation of sumoylated PML . The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) .
Cellular Localization Nucleus Cytoplasm Nucleus, PML body. Upon TGF-beta treatment, translocates from nucleus to cytosol.
Tissue Specificity Broadly expressed.
Swiss-Prot Key

 

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