Anti-ARRB2 Antibody

Rs. 61,689.00
SKU stj22693

General Information

Product name Anti-ARRB2 Antibody
Short Description Rabbit polyclonal to ARRB2
Description Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:1000
IHC 1:20 - 1:50
Protein Name Anti-ARRB2 Antibody
Immunogen A synthetic peptide of human ARRB2
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 46.1 kDa
Database Links
Alternative Names ARRB2Beta-arrestin-2 antibodyArrestin beta-2 antibodyNon-visual arrestin-3ARRB2 antibodyARB2 antibodyARR2
Function Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes, During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein
Cellular Localization Cytoplasm, Nucleus, Cell membrane, Membrane, clathrin-coated pit, Cytoplasmic vesicle.
Tissue Specificity
Swiss-Prot Key

 

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