Anti-ASGR1 Antibody

Rs. 45,619.00
SKU stj28951

General Information

Product name Anti-ASGR1 Antibody
Short Description Rabbit polyclonal to ASGR1
Description This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Applications WB,IHC
Dilution range WB 1:1000 - 1:4000
IHC 1:50 - 1:200
Protein Name Anti-ASGR1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ASGR1 (NP_001662.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 33.2 kDa
Database Links
Alternative Names ASGR1Asialoglycoprotein receptor 1 antibodyASGP-R 1 antibodyASGPR 1 antibodyC-type lectin domain family 4 member H1 antibodyHepatic lectin H1 antibodyHL-1ASGR1 antibodyCLEC4H1
Function Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed, The receptor recognizes terminal galactose and N-acetylgalactosamine units, After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated, The receptor then returns to the cell membrane surface
Cellular Localization Isoform H1a: Membrane
Tissue Specificity Expressed exclusively in hepatic parenchymal cells
Swiss-Prot Key

 

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