Anti-ASGR2 Antibody

Rs. 45,619.00
SKU stj115884

General Information

Product name Anti-ASGR2 Antibody
Short Description Rabbit polyclonal to ASGR2
Description This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Asialoglycoprotein receptor 2ASGP-R 2ASGPR 2C-type lectin domain family 4 member H2Hepatic lectin H2HL-2
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 131-287 of human ASGR2 (NP_550435.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 35.1 kDa
Database Links
Alternative Names ASGR2Asialoglycoprotein receptor 2 antibodyASGP-R 2 antibodyASGPR 2 antibodyC-type lectin domain family 4 member H2 antibodyHepatic lectin H2 antibodyHL-2ASGR2 antibodyCLEC4H2
Function Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed, The receptor recognizes terminal galactose and N-acetylgalactosamine units, After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated, The receptor then returns to the cell membrane surface
Cellular Localization Membrane
Tissue Specificity Expressed exclusively in hepatic parenchymal cells
Swiss-Prot Key

 

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