Anti-ASNA1 Antibody

Rs. 68,577.00
SKU stj71016

General Information

Product name Anti-ASNA1 Antibody
Short Description Goat polyclonal to ASNA1
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-ASNA1 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 38.8 kDa
Database Links
Alternative Names ASNA1ATPase ASNA1 ASNA1 antibodyARSA antibodyTRC40
Function ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum, Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol, This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion, This process is regulated by ATP binding and hydrolysis, ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins, ATP hydrolysis is required for insertion, Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity), May be involved in insulin signaling,
Cellular Localization Cytoplasm, Endoplasmic reticulum, Nucleus, nucleolus
Tissue Specificity Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle,
Swiss-Prot Key

 

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