Anti-ASPSCR1 Antibody

Rs. 45,619.00
SKU stj29617

General Information

Product name Anti-ASPSCR1 Antibody
Short Description Rabbit polyclonal to ASPSCR1
Description The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found.
Applications WB,IHC,IF,IP
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:50 - 1:100
Protein Name Anti-ASPSCR1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 284-553 of human ASPSCR1 (NP_076988.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 60.2 kDa
Database Links
Alternative Names ASPSCR1Tether containing UBX domain for GLUT4 antibodyAlveolar soft part sarcoma chromosomal region candidate gene 1 protein antibodyAlveolar soft part sarcoma locus antibodyRenal papillary cell carcinoma protein 17 antibodyUBX domain-containing protein 9ASPSCR1 antibodyASPL antibodyRCC17 antibodyTUG antibodyUBXD9 antibodyUBXN9
Function Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin, Modulates the amount of GLUT4 that is available at the cell surface (By similarity), Enhances VCP methylation catalyzed by VCPKMT.
Cellular Localization Endomembrane system
Tissue Specificity Ubiquitous, highly expressed in testis, heart, skeletal muscle and pancreas.
Swiss-Prot Key

 

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