Anti-ATF-2 antibody

Rs. 50,211.00
SKU stj91751

General Information

Product name Anti-ATF-2 antibody
Short Description
Description Rabbit polyclonal to ATF-2.
Applications WB,IHC,IP,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IP 1:200-500ELISA 1:20000
Protein Name Anti-ATF-2 antibody
Immunogen Synthesized peptide derived from human ATF-2 around the non-phosphorylation site of T71.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat,Monkey
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 52 kDa
Database Links
Alternative Names Cyclic AMP-dependent transcription factor ATF-2 antibody
cAMP-dependent transcription factor ATF-2 antibody
Activating transcription factor 2 antibody
Cyclic AMP-responsive element-binding protein 2 antibody
CREB-2 antibody
cAMP-responsive element-binding protein 2 antibody
HB16 antibody
Histone acetyltransferase ATF2 antibody
cAMP response element-binding protein CRE-BP1 antibody
CREB2 antibody
CREBP1 antibody
Function Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
Cellular Localization Nucleus. Cytoplasm. Mitochondrion outer membrane. Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).
Tissue Specificity Ubiquitously expressed, with more abundant expression in the brain.
Swiss-Prot Key

 

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