Anti-ATF4 Antibody

Rs. 45,619.00
SKU stj22704

General Information

Product name Anti-ATF4 Antibody
Short Description Rabbit polyclonal to ATF4
Description This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ATF4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human ATF4 (NP_001666.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 38.6 kDa
Database Links
Alternative Names ATF4Cyclic AMP-dependent transcription factor ATF-4 antibodycAMP-dependent transcription factor ATF-4 antibodyActivating transcription factor 4 antibodyCyclic AMP-responsive element-binding protein 2 antibodyCREB-2 antibodycAMP-responsive element-binding protein 2 antibodyDNA-binding protein TAXREB67 antibodyTax-responsive enhancer element-binding protein 67 antibodyTaxREB67ATF4 antibodyCREB2 antibodyTXREB
Function Transcriptional activator, Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters, Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity), It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I, Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress, In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA, Activates transcription of SIRT4, Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4, Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes, During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors.
Cellular Localization Cytoplasm.
Tissue Specificity
Swiss-Prot Key

 

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