Anti-ATG4C Antibody

Rs. 45,619.00
SKU stj29533

General Information

Product name Anti-ATG4C Antibody
Short Description Rabbit polyclonal to ATG4C
Description Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ATG4C Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ATG4C (NP_116241.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 52.5 kDa
Database Links
Alternative Names ATG4CCysteine protease ATG4C ATG4C antibodyAPG4C antibodyAUTL1 antibodyAUTL3
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy, Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity), Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine, Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy, Has also an activity of delipidating enzyme for the PE-conjugated forms.
Cellular Localization Cytoplasm
Tissue Specificity Highly expressed in skeletal muscle, heart, liver and testis.
Swiss-Prot Key

 

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