Anti-Atg4C antibody

Rs. 50,211.00
SKU stj91760

General Information

Product name Anti-Atg4C antibody
Short Description
Description Rabbit polyclonal to Atg4C.
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000
Protein Name Anti-Atg4C antibody
Immunogen Synthesized peptide derived from human Atg4C
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Monkey
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 49 kDa
Database Links
Alternative Names Cysteine protease ATG4C antibody
AUT-like 3 cysteine endopeptidase antibody
Autophagin-3 antibody
Autophagy-related cysteine endopeptidase 3 antibody
Autophagy-related protein 4 homolog C antibody
APG4C antibody
AUTL1 antibody
AUTL3 antibody
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation . Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Cellular Localization Cytoplasm
Tissue Specificity Highly expressed in skeletal muscle, heart, liver and testis.
Swiss-Prot Key

 

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