Anti-ATL1 Antibody

Rs. 45,619.00
SKU stj27255

General Information

Product name Anti-ATL1 Antibody
Short Description Rabbit polyclonal to ATL1
Description The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-ATL1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ATL1 (NP_056999.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 63.5 kDa
Database Links
Alternative Names ATL1Atlastin-1 ATL1 antibodyGBP3 antibodySPG3A
Function GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes, Functions in endoplasmic reticulum tubular network biogenesis , May also regulate Golgi biogenesis, May regulate axonal development.
Cellular Localization Endoplasmic reticulum membrane.
Tissue Specificity Expressed predominantly in the adult and fetal central nervous system, measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues, detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain, expressed in upper and lower motor neurons (at protein level).
Swiss-Prot Key

 

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