Anti-ATP5A1 Antibody

Rs. 45,619.00
SKU stj28157

General Information

Product name Anti-ATP5A1 Antibody
Short Description Rabbit polyclonal to ATP5F1A
Description This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16.
Applications WB,IHC,IF,IP
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
IP 1:50 - 1:200
Protein Name Anti-ATP5A1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ATP5A1 (NP_004037.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 59.8 kDa
Database Links
Alternative Names ATP5F1AATP synthase subunit alpha antibodymitochondrial antibodyATP synthase F1 subunit alphaATP5F1A antibodyATP5A antibodyATP5A1 antibodyATP5AL2 antibodyATPM
Function Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain, F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk, During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation, Subunits alpha and beta form the catalytic core in F(1), Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits, Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
Cellular Localization Mitochondrion inner membrane.
Tissue Specificity Fetal lung, heart, liver, gut and kidney, expressed at higher levels in the fetal brain, retina and spinal cord.
Swiss-Prot Key

 

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