Anti-ATP6V0A4 Antibody

Rs. 45,619.00
SKU stj29728

General Information

Product name Anti-ATP6V0A4 Antibody
Short Description Rabbit polyclonal to ATP6V0A4
Description This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ATP6V0A4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ATP6V0A4 (NP_065683.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 96.4 kDa
Database Links
Alternative Names ATP6V0A4V-type proton ATPase 116 kDa subunit a isoform 4 antibodyV-ATPase 116 kDa isoform a4 antibodyVacuolar proton translocating ATPase 116 kDa subunit a isoform 4 antibodyVacuolar proton translocating ATPase 116 kDa subunit a kidney isoformATP6V0A4 antibodyATP6N1B antibodyATP6N2
Function Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney.
Cellular Localization Apical cell membrane
Tissue Specificity Expressed in adult and fetal kidney, found in the inner ear.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF