Anti-ATP6V1B1 Antibody

Rs. 45,619.00
SKU stj28956

General Information

Product name Anti-ATP6V1B1 Antibody
Short Description Rabbit polyclonal to ATP6V1B1
Description This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ATP6V1B1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ATP6V1B1 (NP_001683.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 56.8 kDa
Database Links
Alternative Names ATP6V1B1V-type proton ATPase subunit B antibodykidney isoform antibodyV-ATPase subunit B 1 antibodyEndomembrane proton pump 58 kDa subunit antibodyVacuolar proton pump subunit B 1ATP6V1B1 antibodyATP6B1 antibodyVATB antibodyVPP3
Function Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase, V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells
Cellular Localization Endomembrane system
Tissue Specificity Expressed in the cochlea and endolymphatic sac.
Swiss-Prot Key

 

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