Anti-ATR Antibody

Rs. 45,619.00
SKU stj115886

General Information

Product name Anti-ATR Antibody
Short Description Rabbit polyclonal to ATR
Description The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Serine/threonine-protein kinase ATR
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 400-650 of human ATR (NP_001175.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 301.4 kDa
Database Links
Alternative Names ATRSerine/threonine-protein kinase ATR ATR antibodyFRP1
Function Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor, Recognizes the substrate consensus sequence [ST]-Q, Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis, Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism, Required for FANCD2 ubiquitination, Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
Cellular Localization Nucleus.
Tissue Specificity Ubiquitous, with highest expression in testis, isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.
Swiss-Prot Key

 

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