Anti-AURKA Antibody

Rs. 45,619.00
SKU stj22742

General Information

Product name Anti-AURKA Antibody
Short Description Rabbit polyclonal to AURKA
Description The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-AURKA Antibody
Immunogen A synthetic peptide of human AURKA
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 45.8 kDa
Database Links
Alternative Names AURKAAurora kinase A AURKA antibodyAIK antibodyAIRK1 antibodyARK1 antibodyAURA antibodyAYK1 antibodyBTAK antibodyIAK1 antibodySTK15 antibodySTK6
Function Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression, Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis, Required for initial activation of CDK1 at centrosomes, Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2, Regulates KIF2A tubulin depolymerase activity, Required for normal axon formation, Plays a role in microtubule remodeling during neurite extension, Important for microtubule formation and/or stabilization, Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53, Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity, Necessary for proper cilia disassembly prior to mitosis.
Cellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Tissue Specificity Highly expressed in testis and weakly in skeletal muscle, thymus and spleen, also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines
Swiss-Prot Key

 

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