Anti-AURKB Antibody

Rs. 68,577.00
SKU stj73294

General Information

Product name Anti-AURKB Antibody
Short Description Goat polyclonal to AURKB
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-AURKB Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 39.3 kDa
Database Links
Alternative Names AURKBAurora kinase B AURKB antibodyAIK2 antibodyAIM1 antibodyAIRK2 antibodyARK2 antibodySTK1 antibodySTK12 antibodySTK5
Function Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis, The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly, Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis, Required for central/midzone spindle assembly and cleavage furrow formation, Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis , A positive feedback between HASPIN and AURKB contributes to CPC localization, AURKB is also required for kinetochore localization of BUB1 and SGO1, Phosphorylation of p53/TP53 negatively regulates its transcriptional activity, Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes,
Cellular Localization Nucleus, Chromosome, Chromosome, centromere, Cytoplasm, cytoskeleton, spindle, Midbody,
Tissue Specificity High level expression seen in the thymus, it is also expressed in the spleen, lung, testis, colon, placenta and fetal liver, expressed during s and g2/m phase and expression is up-regulated in cancer cells during m phase,
Swiss-Prot Key

 

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