Anti-AXIN2 Antibody

Rs. 45,619.00
SKU stj26209

General Information

Product name Anti-AXIN2 Antibody
Short Description Rabbit polyclonal to AXIN2
Description The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Applications WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Anti-AXIN2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human AXIN2 (NP_004646.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 93.6 kDa
Database Links
Alternative Names AXIN2Axin-2 antibodyAxin-like protein antibodyAxil antibodyAxis inhibition protein 2 antibodyConductinAXIN2
Function Inhibitor of the Wnt signaling pathway, Down-regulates beta-catenin, Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).
Cellular Localization Cytoplasm
Tissue Specificity Expressed in brain and lymphoblast
Swiss-Prot Key

 

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