Anti-BACE1 Antibody

Rs. 45,619.00
SKU stj29911

General Information

Product name Anti-BACE1 Antibody
Short Description Rabbit polyclonal to BACE1
Description This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-BACE1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 22-322 of human BACE1 (NP_036236.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 55.8 kDa
Database Links
Alternative Names BACE1Beta-secretase 1 BACE1 antibodyBACE antibodyKIAA1149
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP), Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Cellular Localization Membrane
Tissue Specificity Expressed at high levels in the brain and pancreas, in the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
Swiss-Prot Key

 

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