Anti-BAG1 Antibody

Rs. 45,619.00
SKU stj22756

General Information

Product name Anti-BAG1 Antibody
Short Description Rabbit polyclonal to BAG1
Description The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:20 - 1:100
Protein Name Anti-BAG1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human BAG1 (NP_001165886.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 38.8 kDa
Database Links
Alternative Names BAG1BAG family molecular chaperone regulator 1 antibodyBAG-1 antibodyBcl-2-associated athanogene 1BAG1 antibodyHAP
Function Co-chaperone for HSP70 and HSC70 chaperone proteins, Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release, Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70.
Cellular Localization Nucleus, Cytoplasm, Cytoplasm, Nucleus.
Tissue Specificity Isoform 4 is the most abundantly expressed isoform, it is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium, isoform 1 is expressed in the ovary and testis, isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines, isoform 1 is expressed in the prostate, breast and leukemia cell lines, isoform 3 is the least abundant isoform in tumor cell lines (at protein level).
Swiss-Prot Key

 

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