General Information
| Product name | Anti-BAIAP2 Antibody |
|---|---|
| Short Description | Rabbit polyclonal to BAIAP2 |
| Description | The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Applications | WB,IHC,IF |
| Dilution range | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Protein Name | Anti-BAIAP2 Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 362-521 of human BAIAP2 (NP_059344.1). |
| Storage Instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Type of Usage | For Research Use Only (RUO). |
Product Properties
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Isotype | IgG |
| Formulation | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Target
| Gene ID | |
|---|---|
| Gene Symbol | |
| Molecular Weight | 60.9 kDa |
| Database Links | |
| Alternative Names | BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 antibodyBAI-associated protein 2 antibodyBAI1-associated protein 2 antibodyProtein BAP2 antibodyFas ligand-associated factor 3 antibodyFLAF3 antibodyInsulin receptor substrate p53/p58 antibodyIRS-58 antibodyIRSp53/58 antibodyInsulin receptor substrate protein of 53 kDa antibodyIRSp53 antibodyInsulin receptor substrate p53BAIAP2 |
| Function | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins, Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling, Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex, Plays a role in neurite growth, Acts syngeristically with ENAH to promote filipodia formation, Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection, Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. |
| Cellular Localization | Cytoplasm, Membrane |
| Tissue Specificity | Isoform 1 and isoform 4 are expressed almost exclusively in brain, isoform 4 is barely detectable in placenta, prostate and testis, a short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. |
| Swiss-Prot Key |