Anti-BAIAP2 Antibody

Rs. 45,619.00
SKU stj27290

General Information

Product name Anti-BAIAP2 Antibody
Short Description Rabbit polyclonal to BAIAP2
Description The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-BAIAP2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 362-521 of human BAIAP2 (NP_059344.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 60.9 kDa
Database Links
Alternative Names BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 antibodyBAI-associated protein 2 antibodyBAI1-associated protein 2 antibodyProtein BAP2 antibodyFas ligand-associated factor 3 antibodyFLAF3 antibodyInsulin receptor substrate p53/p58 antibodyIRS-58 antibodyIRSp53/58 antibodyInsulin receptor substrate protein of 53 kDa antibodyIRSp53 antibodyInsulin receptor substrate p53BAIAP2
Function Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins, Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling, Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex, Plays a role in neurite growth, Acts syngeristically with ENAH to promote filipodia formation, Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection, Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
Cellular Localization Cytoplasm, Membrane
Tissue Specificity Isoform 1 and isoform 4 are expressed almost exclusively in brain, isoform 4 is barely detectable in placenta, prostate and testis, a short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.
Swiss-Prot Key

 

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