Anti-BAK1 Antibody

Rs. 45,619.00
SKU stj114891

General Information

Product name Anti-BAK1 Antibody
Short Description Rabbit polyclonal to BAK1
Description The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Bcl-2 homologous antagonist/killerApoptosis regulator BAKBcl-2-like protein 7Bcl2-L-7
Immunogen A synthetic peptide of human BAK1
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 23.4 kDa
Database Links
Alternative Names BAK1Bcl-2 homologous antagonist/killer antibodyApoptosis regulator BAK antibodyBcl-2-like protein 7 antibodyBcl2-L-7BAK1 antibodyBAK antibodyBCL2L7 antibodyCDN1
Function Plays a role in the mitochondrial apoptosic process, Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM, This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
Cellular Localization Mitochondrion membrane
Tissue Specificity Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle
Swiss-Prot Key

 

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