Anti-BAZ1B Antibody

Rs. 45,619.00
SKU stj114419

General Information

Product name Anti-BAZ1B Antibody
Short Description Rabbit polyclonal to BAZ1B
Description This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Tyrosine-protein kinase BAZ1B
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human BAZ1B (NP_115784.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 170.9 kDa
Database Links
Alternative Names BAZ1BTyrosine-protein kinase BAZ1B BAZ1B antibodyWBSC10 antibodyWBSCR10 antibodyWBSCR9 antibodyWSTF
Function Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator, Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph), H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress, Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure, The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes, In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.
Cellular Localization Nucleus.
Tissue Specificity Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary
Swiss-Prot Key

 

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