Anti-Bbs1 Antibody

Rs. 57,098.00
SKU stj72455

General Information

Product name Anti-Bbs1 Antibody
Short Description Goat polyclonal to Bbs1 (mouse)
Description
Applications ELISA
Dilution range
Protein Name Anti-Bbs1 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 65.1 kDa
Database Links
Alternative Names Anti-Bbs1 (mouse) Antibody
Function The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia, The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function, This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome, Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane, Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane, The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation, Required for proper BBSome complex assembly (By similarity), Plays a role in olfactory cilium biogenesis/maintenance and trafficking and is essential for the localization of the BBSome complex in the olfactory sensory neurons cilia ,
Cellular Localization Cell projection, cilium membrane
Tissue Specificity
Swiss-Prot Key

 

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