Anti-Bcl-x antibody

Rs. 50,211.00
SKU stj91844

General Information

Product name Anti-Bcl-x antibody
Short Description
Description Rabbit polyclonal to Bcl-x.
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-Bcl-x antibody
Immunogen Synthesized peptide derived from human Bcl-x around the non-phosphorylation site of T115.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 24 kDa
Database Links
Alternative Names Bcl-2-like protein 1 antibody
Bcl2-L-1 antibody
Apoptosis regulator Bcl-X antibody
BCL2L antibody
BCLX antibody
Function Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release . Isoform Bcl-X(S) promotes apoptosis.
Cellular Localization Isoform Bcl-X(L): Mitochondrion inner membrane Mitochondrion outer membrane Mitochondrion matrix Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Cytoplasm, cytosol Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane. After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner . Localizes to the centrosome when phosphorylated at Ser-49.
Tissue Specificity Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Swiss-Prot Key

 

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