Anti-BCL2L11 Antibody

Rs. 45,619.00
SKU stj114428

General Information

Product name Anti-BCL2L11 Antibody
Short Description Rabbit polyclonal to BCL2L11
Description The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
Applications IHC,IF
Dilution range IHC 1:50 - 1:100
IF 1:50 - 1:100
Protein Name Bcl-2-like protein 11Bcl2-L-11Bcl2-interacting mediator of cell death
Immunogen Recombinant protein of human BCL2L11
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 22.2 kDa
Database Links
Alternative Names BCL2L11Bcl-2-like protein 11 antibodyBcl2-L-11 antibodyBcl2-interacting mediator of cell deathBCL2L11 antibodyBIM
Function Induces apoptosis and anoikis, Isoform BimL is more potent than isoform BimEL, Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS, Isoform Bim-gamma induces apoptosis, Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway, Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Cellular Localization Endomembrane system
Tissue Specificity Isoform bimel, isoform biml and isoform bims are the predominant isoforms and are widely expressed with tissue-specific variation, isoform bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
Swiss-Prot Key

 

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