Anti-BEST1 Antibody

Rs. 45,619.00
SKU stj116005

General Information

Product name Anti-BEST1 Antibody
Short Description Rabbit polyclonal to BEST1
Description This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Bestrophin-1TU15BVitelliform macular dystrophy protein 2
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 376-585 of human BEST1 (NP_004174.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 67.7 kDa
Database Links
Alternative Names BEST1Bestrophin-1 antibodyTU15B antibodyVitelliform macular dystrophy protein 2BEST1 antibodyVMD2
Function Forms calcium-sensitive chloride channels, Highly permeable to bicarbonate.
Cellular Localization Cell membrane
Tissue Specificity Predominantly expressed in the basolateral membrane of the retinal pigment epithelium
Swiss-Prot Key

 

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