Anti-BIN1 Antibody

Rs. 45,619.00
SKU stj22799

General Information

Product name Anti-BIN1 Antibody
Short Description Rabbit polyclonal to BIN1
Description This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:20 - 1:50
Protein Name Anti-BIN1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 230-409 of human BIN1 (NP_647601.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 64.7 kDa
Database Links
Alternative Names BIN1Myc box-dependent-interacting protein 1 antibodyAmphiphysin II antibodyAmphiphysin-like protein antibodyBox-dependent myc-interacting protein 1 antibodyBridging integrator 1BIN1 antibodyAMPHL
Function May be involved in regulation of synaptic vesicle endocytosis, May act as a tumor suppressor and inhibits malignant cell transformation
Cellular Localization Isoform BIN1: Nucleus
Tissue Specificity Ubiquitous, highest expression in the brain and muscle, isoform iia is expressed only in the brain where it is concentrated in axon initial segments and nodes of ranvier, isoform bin1 is widely expressed with highest expression in skeletal muscle.
Swiss-Prot Key

 

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