Anti-BIRC3 Antibody

Rs. 68,577.00
SKU stj72373

General Information

Product name Anti-BIRC3 Antibody
Short Description Goat polyclonal to BIRC3
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-BIRC3 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 68.4 kDa
Database Links
Alternative Names BIRC3Baculoviral IAP repeat-containing protein 3 BIRC3 antibodyAPI2 antibodyMIHC antibodyRNF49
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis, Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling, The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10, Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs), Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner, Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8,
Cellular Localization Cytoplasm
Tissue Specificity Highly expressed in fetal lung, and kidney, in the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes
Swiss-Prot Key

 

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