Anti-BLK Antibody

Rs. 45,619.00
SKU stj29563

General Information

Product name Anti-BLK Antibody
Short Description Rabbit polyclonal to BLK
Description This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-BLK Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human BLK (NP_001706.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 57.7 kDa
Database Links
Alternative Names BLKTyrosine-protein kinase Blk BLK
Function Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling, B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors, Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation, Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor, Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207', Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C, With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation, Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation, In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
Cellular Localization Cell membrane.
Tissue Specificity Expressed in lymphatic organs, pancreatic islets, leydig cells, striate ducts of salivary glands and hair follicles.
Swiss-Prot Key

 

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