Anti-BMI1 Antibody

Rs. 45,619.00
SKU stj22809

General Information

Product name Anti-BMI1 Antibody
Short Description Rabbit polyclonal to BMI1
Description This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
Applications WB,IP
Dilution range WB 1:500 - 1:2000
IP 1:50 - 1:100
Protein Name Anti-BMI1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 120-326 of human BMI1 (NP_005171.4).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 36.9 kDa
Database Links
Alternative Names BMI1Polycomb complex protein BMI-1 antibodyPolycomb group RING finger protein 4 antibodyRING finger protein 51BMI1 antibodyPCGF4 antibodyRNF51
Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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