Anti-BMPR2 Antibody

Rs. 45,619.00
SKU stj27633

General Information

Product name Anti-BMPR2 Antibody
Short Description Rabbit polyclonal to BMPR2
Description This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
Applications WB,IF
Dilution range WB 1:200 - 1:1000
Protein Name Anti-BMPR2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 739-1038 of human BMPR2 (NP_001195.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 115.2 kDa
Database Links
Alternative Names BMPR2Bone morphogenetic protein receptor type-2 antibodyBMP type-2 receptor antibodyBMPR-2BMPR2 antibodyPPH1
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases, Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, Binds to BMP7, BMP2 and, less efficiently, BMP4, Binding is weak but enhanced by the presence of type I receptors for BMPs, Mediates induction of adipogenesis by GDF6.
Cellular Localization Cell membrane
Tissue Specificity Highly expressed in heart and liver
Swiss-Prot Key

 

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