Anti-BNIP3 Antibody

Rs. 45,619.00
SKU stj117226

General Information

Product name Anti-BNIP3 Antibody
Short Description Rabbit polyclonal to BNIP3
Description This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation.
Applications IF
Dilution range IF 1:50 - 1:200
Protein Name BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human BNIP3 (NP_004043.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 27.8 kDa
Database Links
Alternative Names BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3BNIP3 antibodyNIP3
Function Apoptosis-inducing protein that can overcome BCL2 suppression, May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2, Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria, The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix, Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Cellular Localization Mitochondrion, Mitochondrion outer membrane
Tissue Specificity
Swiss-Prot Key

 

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