Anti-BRD4 Antibody

Rs. 45,619.00
SKU stj116172

General Information

Product name Anti-BRD4 Antibody
Short Description Rabbit polyclonal to BRD4
Description The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Bromodomain-containing protein 4Protein HUNK1
Immunogen Recombinant protein of human BRD4
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 152.2 kDa
Database Links
Alternative Names BRD4Bromodomain-containing protein 4 antibodyProtein HUNK1BRD4 antibodyHUNK1
Function Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation, Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure, During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters: BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II, Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II, According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II
Cellular Localization Nucleus, Chromosome.
Tissue Specificity Ubiquitously expressed.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed