Anti-Brn-3a antibody

Rs. 50,211.00
SKU stj91894

General Information

Product name Anti-Brn-3a antibody
Short Description
Description Rabbit polyclonal to Brn-3a.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:5000
Protein Name Anti-Brn-3a antibody
Immunogen Synthesized peptide derived from human Brn-3a
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 42 kDa
Database Links
Alternative Names POU domain, class 4, transcription factor 1 antibody
Brain-specific homeobox/POU domain protein 3A antibody
Brain-3A antibody
Brn-3A antibody
Homeobox/POU domain protein RDC-1 antibody
Oct-T1 antibody
BRN3A antibody
RDC1 antibody
Function Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site. Isoform 2: Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have antiapoptotic effect on neuronal cells.
Cellular Localization Nucleus Cytoplasm
Tissue Specificity Expressed in the brain and the retina. Present in the developing brain, spinal cord and eye.
Swiss-Prot Key

 

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