Anti-c-FLIP antibody

Rs. 50,211.00
SKU stj92242

General Information

Product name Anti-c-FLIP antibody
Short Description
Description Rabbit polyclonal to c-FLIP.
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000
Protein Name Anti-c-FLIP antibody
Immunogen Synthesized peptide derived from human c-FLIP
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 55 kDa
Database Links
Alternative Names CASP8 and FADD-like apoptosis regulator antibody
Caspase homolog antibody
CASH antibody
Caspase-eight-related protein antibody
Casper antibody
Caspase-like apoptosis regulatory protein antibody
CLARP antibody
Cellular FLICE-like inhibitory protein antibody
FADD-like antiapoptotic molecule 1 antibody
FLAME-1 antibody
Inhibitor of FLICE antibody
I-FLICE antibody
MACH-related inducer of toxicity antibody
MRIT antibody
Usurpin antibody
CASP8 and FADD-like apoptosis regulator subunit p43 antibody
CASP8 and FADD-like apoptosis regulator subunit p12 antibody
CASH antibody
CASP8AP1 antibody
CLARP antibody
MRIT antibody
Function Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Cellular Localization
Tissue Specificity Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Swiss-Prot Key

 

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