Anti-C4BPA Antibody

Rs. 45,619.00
SKU stj29962

General Information

Product name Anti-C4BPA Antibody
Short Description Rabbit polyclonal to C4BPA
Description This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster.
Applications WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Anti-C4BPA Antibody
Immunogen A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human C4BPA (NP_000706.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 67 kDa
Database Links
Alternative Names C4BPAC4b-binding protein alpha chain antibodyC4bp antibodyProline-rich protein antibodyPRPC4BPA antibodyC4BP
Function Controls the classical pathway of complement activation, It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b, It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a, Alpha chain binds C4b, It interacts also with anticoagulant protein S and with serum amyloid P component
Cellular Localization Secreted
Tissue Specificity Chylomicrons in the plasma
Swiss-Prot Key

 

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