Anti-C4BPB Antibody

Rs. 45,619.00
SKU stj28445

General Information

Product name Anti-C4BPB Antibody
Short Description Rabbit polyclonal to C4BPB
Description This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:100
Protein Name Anti-C4BPB Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 18-251 of human C4BPB (NP_001017364.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 28.4 kDa
Database Links
Alternative Names C4BPBC4b-binding protein beta chainC4BPB
Function Controls the classical pathway of complement activation, It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b, It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a, It also interacts with anticoagulant protein S and with serum amyloid P component, The beta chain binds protein S
Cellular Localization Secreted
Tissue Specificity
Swiss-Prot Key

 

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